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Vitamin D receptor activation inhibits the induction of pro-inflammatory cytokines in BV2 microglial cells. Vitamin D3 receptor (VDR) activation is suggested to regulate inflammatory responses and might be involved in the pathogenesis of various neurological diseases. We report here that the pro-inflammatory cytokines, interleukin (IL)-1β, IL-6 and tumour necrosis factor (TNF)-α, were significantly increased in lipopolysaccharide (LPS)-stimulated BV2 microglial cells, but this induction was significantly suppressed by vitamin D3 or 1α,25(OH)2-vitamin D3 (VD3), as well as by VDR agonists, even though they were not effective against TNF-α, whereas these were more potent than an anti-inflammatory cytokine, IL-10, a decoy receptor for IL-10, or an inhibitor of nuclear factor-κB. The activation of VDR inhibited the phosphorylation of IκB, the degradation of IkB, and the nuclear translocation of NF-κB p65. Furthermore, the activation of VDR inhibited the phosphorylation of IKKα/β. Together, these results suggest that VDR activation is effective for the inhibition of pro-inflammatory cytokine induction by LPS, and may also be useful for the development of neuroprotective agents.Does the work capacity limit the contribution of fitness and endurance training to maximal oxygen uptake? It has been a common opinion that fitness-trained individuals are better suited for endurance training than for endurance-trained individuals. However, this viewpoint is not supported by scientific evidence. In the present study, the effects of endurance training on the maximal aerobic power (VO(2max)) were compared between well-trained (WT) runners, who ran at a VO(2max) ranging from 60 to 80 ml/kg/min, and untrained individuals (UT), who ran at the same VO(2max) range. The UT group included 22 healthy men (19-26 years) and the WT group consisted of 16 well-trained male cross-country runners (18-26 years). When the VO(2max) of the UT group was compared with those of the WT group, the group of the UT runners did not exhibit any significant differences in their VO(2max) values. Although the group of the WT runners showed VO(2max) values that were approximately 10% higher than those
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